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  • Title: Modification of visual callosal projections in rats.
    Author: Cusick CG, Lund RD.
    Journal: J Comp Neurol; 1982 Dec 20; 212(4):385-98. PubMed ID: 7161416.
    Abstract:
    The effects of a variety of developmental manipulations on the distribution of the callosal pathway to visual cortex were examined by using the Fink Heimer technique in adult rats. First, the callosal projections in albino and pigmented rats were compared and found to be similar. The callosal pathway was limited in area 17 to a region adjoining its lateral border with area 18a. Second, dark-reared rats were found to have normal callosal projections. Third, rats bilaterally enucleated at birth and expanded callosal inputs within area 17. Fourth, monocular enucleation at birth produced an expanded callosal pathway to area 17 contralateral to the enucleation and normal callosal projections to the opposite hemisphere. The expanded callosal inputs after enucleation showed a patchy distribution and usually avoided the most medial part of area 17. Fifth, a reduction in the callosal projections to the area 17/18a border was found after neonatal unilateral optic tract lesions. Sixth, expanded callosal inputs to area 17 were found following unilateral thalamic lesions at birth. The abnormal projection occupied mainly layers IV and III. The results of the different experiments indicate that the detailed distribution of the visual callosal projection within area 17 depends heavily on the organization of the retinogeniculocortical pathways to each hemisphere.
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