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  • Title: Treatment of vaginal trichomoniasis. Single, 2-gram dose of metronidazole as compared with a seven-day course.
    Author: Aubert JM, Sesta HJ.
    Journal: J Reprod Med; 1982 Dec; 27(12):743-5. PubMed ID: 7161754.
    Abstract:
    Although a single, 2-gm dose of metronidazole has been approved for the treatment of vaginal trichomoniasis, this regimen has not gained general acceptance. We compared the single, 2-gm dose versus the regimen of 250 mg administered three times daily for seven days. Two hundred sixty-three women with vaginal trichomoniasis were treated. One hundred seventy returned for follow-up. Of them, 96 received the single, 2-gm dose and 74 the seven-day treatment. The cure rates were 93.8% and 97.3%, respectively, and were not significantly different. These data compare favorably with those from previous studies. The side effects were minimal and occurred with greater frequency in the group receiving the single, 2-gm dose; nevertheless, the difference was not significant. We recommend the 2-gm regimen for the treatment of vaginal trichomoniasis because of its easy administration, better patient compliance and lower cost.
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