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  • Title: Accessory function of aging Kupffer cells with different lymphocyte populations.
    Author: Heil MF, Garvey JS.
    Journal: J Reticuloendothel Soc; 1982 Oct; 32(4):287-96. PubMed ID: 7161765.
    Abstract:
    The present studies show that rat Kupffer cells are capable of both suppression and enhancement of mitogen responses. Studies were conducted using the T-cell mitogens concanavalin A and phytohemmaglutinin, as well as the rat B-cell mitogen Mycoplasma neurolyticum. Whereas Kupffer cell concentrations of 1 X 10(5)/well significantly suppressed the T- and B-mitogen response of both spleen nonadherent and peripheral blood lymphocytes, enhancement was restricted to the T-cell mitogen responses. No tissue-related differences were found in the suppression. However, both tissue differences and age-related changes were observed with enhancement. Age-related changes in the Kupffer cell resulted in a decreased enhancement of the proliferative response of spleen to concanavalin A and an increased response of peripheral blood lymphocytes.
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