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  • Title: Role of iron and influence of antiinflammatory drugs on oxygen-derived free radical production and reactivity.
    Author: Cleland LG, Betts WH, Vernon-Roberts B, Bielicki J.
    Journal: J Rheumatol; 1982; 9(6):885-92. PubMed ID: 7161780.
    Abstract:
    The production of a potent hydroxylating species, presumed to be hydroxyl radical, was studied using hydroxylation of salicylate as a detector system. Oxygen-derived free radicals (ODFR) were generated by (a) autoxidation of ferrous-EDTA chelates and (b) enzymatically (xanthine oxidase/hypoxanthine). Hydroxylation by these ODFR-generating systems was inhibited by superoxide dismutase, hydroxyl radical scavengers and singlet oxygen quenchers. Low concentrations (1 mM-10 mM) of penicillamine stimulated hydroxylation by the autoxidation system, although higher concentrations were inhibitory; all concentrations were inhibitory in the enzymatic system. The chelating agents, diethylenetriamine pentaacetic acid and bathophenanthroline sulphonate, were inhibitory in both systems, as were the long acting anti-rheumatic drugs, gold sodium thiomalate and chloroquine. The mechanisms of hydroxyl radical generation described may have relevance to the mechanisms of ODFR generation occurring in vivo at sites of inflammation.
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