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  • Title: Biochemical pharmacology of cytosine arabinoside.
    Author: Momparler RL.
    Journal: Med Pediatr Oncol; 1982; 10 Suppl 1():45-8. PubMed ID: 7162466.
    Abstract:
    Cytosine arabinoside (Ara-C) is a very potent inhibitor of DNA synthesis in mammalian cells. This inhibition does not appear to be due to the direct inhibition of DNA polymerase by Ara-CTP (triphosphate of Ara-C) because it is a very weak competitive inhibitor of this enzyme. The inhibition of DNA synthesis appears to be due to the incorporation of Ara-C into DNA producing chain termination of polydeoxynucleotide elongation.
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