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  • Title: [Lyophilization protection of hemoglobin by N-acetyltryptophan].
    Author: Saint-Blancard J, Rambourg P, Doucet D.
    Journal: Rev Fr Transfus Immunohematol; 1982 Oct; 25(5):513-25. PubMed ID: 7163731.
    Abstract:
    Measurements of methemoglobin content, different oxyphoric powers, oxygen affinity were made on freeze-dryed hemoglobin without protector and in presence of N-acetyl tryptophan and/or alpha-D glucose. These measurements revealed that, at low concentrations, N-acetyl tryptophan offers a better protection than glucose. Moreover, this acetylated amino-acid decreases the oxygen affinity of hemoglobin (Po(2)50 increased). The two protectors do not seem to compete, but present complementary effects.
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