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  • Title: Platelet-activating factor (PAF-acether): thromboxane-independent synergism with adrenaline on human platelets and recent insights into its mode of action.
    Author: Fouque F, Joseph D, Vargaftig BB.
    Journal: Agents Actions; 1982 Dec; 12(5-6):720-2. PubMed ID: 7164947.
    Abstract:
    The mode of action of PAF-acether on human and rabbit plasma-free platelets is reviewed. PAF-acether and adrenaline synergize to trigger aggregation of human platelets, and this synergism is refractory to aspirin. When degranulated rabbit platelets are stimulated with PAF-acether, with thrombin or with the snake venom component convulxin, aggregation is obtained in the absence of detectable secretion. Collagen-induced aggregation is reduced, and is suppressed when aspirin is applied to the degranulated platelets. The formation of PAF-acether by platelets, and their stimulation by PAF-acether itself, should be added to the newly recognized pathways for platelet stimulation.
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