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  • Title: Induction of metallothionein by zinc in lethal milk mutant mice.
    Author: Piletz JE, Herschman HR.
    Journal: Biochem Genet; 1982 Dec; 20(11-12):1221-33. PubMed ID: 7165696.
    Abstract:
    Adult lethal milk (lm/lm) mutant mice display increased induction of hepatic metallothionein synthesis compared to wild-type mice following the subcutaneous injection of 40 mumol ZnCl2/kg mouse. At this zinc dose the rate of incorporation of [35S] cysteine into hepatic metallothionein in adult (100- to 230-day-old) lm/lm mice was approximately 2.4-fold greater than the rate of incorporation of isotope in wild-type animals. At a higher zinc dose (160 mumol ZnCl2/kg) the incorporation of [35S] cysteine into hepatic metallothionein was similar in lm/lm and wild-type mice. The altered dose-response to zinc administration was not due to a change in hepatic zinc, copper, or manganese levels, to a difference in 65Zn uptake, or to an alteration in 65Zn bound to differential centrifugation fractions of adult lm/lm liver. 65Zn bound to hepatic metallothionein was, however, increased in aging lm/lm mice with symptomatic skin lesions.
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