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  • Title: Levels of alpha-melanotrophin in the human fetal pituitary gland throughout gestation, in adult pituitary gland and in human placenta.
    Author: Wilson JF.
    Journal: Clin Endocrinol (Oxf); 1982 Sep; 17(3):233-42. PubMed ID: 7165967.
    Abstract:
    alpha-Melanotrophin was detected by radioimmunoassay in the human fetal pituitary gland from 11 weeks of gestation. The peak hormone concentration of 3.4 nmol/g pituitary tissue was reached at 17-20 weeks. From 17 to 36 weeks of gestation the total gland content rose gradually from 28 to 102 pmol. During this latter period, the pituitary gland grew some 10-fold, with the result that the alpha-melanotrophin concentration declined steadily to 1.3 nmol/g. In the final month of gestation, both the total gland content and the concentration of alpha-melanotrophin rose significantly to 254 pmol and 2.4 nmol/g respectively. The variations in pituitary gland content of alpha-melanotrophin were consistent with a role for pars intermedia peptides in the fetus. alpha-Melanotrophin-like peptides were not demonstrated in human placental tissue.
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