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  • Title: A patient with gastric carcinoma improved remarkably on intraperitoneal OK-432 therapy.
    Author: Yamagishi H, Ishibashi H, Kodama M, Tanaka T, Harada Y, Hashimoto I.
    Journal: Jpn J Surg; 1982; 12(6):434-41. PubMed ID: 7166915.
    Abstract:
    A patient with an abdominal tumor and gastric cancer was treated with intraperitoneal OK-432 alone. Her general condition improved and the abdominal mass diminished significantly. The fluoroscopic radiography and gastroduodenal fiberscopic examinations revealed a slight improvement. Four months after the initiation of OK-432 therapy, microscopic examination of the biopsy specimen disclosed degenerated tumor cells with a pronounced accumulation of lymphocytes and large monocytes which were ascertained to be macrophages by the fluorescent antibody technique using anti-macrophage serum. This study revealed one possible mechanism of the antitumor action of OK-432.
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