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  • Title: Physiological changes in hyperactive children following the ingestion of food additives.
    Author: Salamy J, Shucard D, Alexander H, Peterson D, Braud L.
    Journal: Int J Neurosci; 1982 May; 16(3-4):241-6. PubMed ID: 7169286.
    Abstract:
    This study attempted to determine if the ingestion of artificial food additives would produce detectable changes in autonomic and/or central nervous system activity in hyperactive children. A single-case experimental design was used which entailed the comparison of heart rate and electroencephalographic (EEG) measures for hyperactive and control children. The physiological measures were obtained prior to and following the ingestion of drinks containing food additives or placebos, which were administered in a double-blind, randomized, crossover procedure. The hyperactive children exhibited a greater degree of physiological activity following both the placebo and the drink containing food additives than did the control children. However, the magnitude of physiological changes in the hyperactive children were greater in response to ingestion of the additives than to placebo. These physiological findings are consistent with behavioural data indicating that some hyperactive children are adversely affected by food additives.
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