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  • Title: Competitive kinetics in the inhibition of sugar intestinal transport by phlorizin, in vivo.
    Author: Rodríguez MJ, Ortiz M, Vázquez A, Lluch M, Ponz F.
    Journal: Rev Esp Fisiol; 1982 Dec; 38(4):397-401. PubMed ID: 7170426.
    Abstract:
    Kinetics of sugar transport inhibition by phlorizin in rat intestine has been studied in vivo. Jejunum lumen was perfused during a series of successive 1 minute periods of absorption. Total sugar absorption was assumed to be the sum of a mediated transport component plus a passive one persisting in the presence of 5 X 10(-4) M phlorizin. The values of transport rates, corrected in this way, showed Michaelis-Menten kinetics and proved that inhibition of D-glucose, D-galactose and 6-deoxy-D-glucose transport by low concentrations of phlorizin (5 X 10(-6) M) displays a typical competitive kinetics (apparent Ki = 4-10 X 10(-6) M) as had been long before reported from in vitro experiments.
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