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  • Title: Effects of naloxone on ethanol and acetaldehyde-induced electroencephalographic changes in rabbits.
    Author: Manzo L, Tartara A, Bo P, Maurelli M, Mazzella G, Savoldi F.
    Journal: Subst Alcohol Actions Misuse; 1982; 3(3):153-61. PubMed ID: 7170675.
    Abstract:
    Rabbits treated with a single IV dose of ethanol, 0.6 g/kg, exhibited rapid EEG synchronization and behavioral changes that were reversed and, in part, prevented by the opiate antagonist, naloxone, 40 micrograms/kg. The continuous intracerebroventricular infusion of acetaldehyde, 10 or 120 micrograms/min. caused biphasic changes with EEG activation and severe bradycardia followed by overt synchrony during the post-infusion period. The results of the present study provide further evidence for the ability of naloxone to counteract some acute effects of ethanol. Moreover, they do not support a role of acetaldehyde itself as mediator of EEG changes associated with mild alcohol intoxication.
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