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  • Title: Combined vitamin A and E therapy prevents retinal electrophysiological deterioration in abetalipoproteinaemia.
    Author: Bishara S, Merin S, Cooper M, Azizi E, Delpre G, Deckelbaum RJ.
    Journal: Br J Ophthalmol; 1982 Dec; 66(12):767-70. PubMed ID: 7171526.
    Abstract:
    Eight patients with abetalipoproteinaemia had the typical ocular, systemic, and laboratory findings of this disease. Combined therapy with vitamins A and E was administered, starting as early as the first day of life and as late as 26 years of age. The patients were followed up for 2-6 years. Electroretinography was undertaken in all cases and electrooculography in some. After initiation of vitamin A and E therapy no progression of disturbed visual function could be detected in any patient. These objective tests of retinal function demonstrated that the combined vitamin A and E therapy may be useful in arresting retinal deterioration in abetalipoproteinaemia.
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