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  • Title: A serum AA-like protein as a common constituent of secondary amyloid fibrils.
    Author: Westermark P, Sletten K.
    Journal: Clin Exp Immunol; 1982 Sep; 49(3):725-31. PubMed ID: 7172504.
    Abstract:
    Amyloid fibrils, purified from the spleen of four patients with amyloidosis associated with rheumatoid arthritis, had protein AA as a major protein. Besides this protein, all four amyloid fibril preparations contained a protein which in size, amino acid composition and N-terminal amino acid sequence was the same as the postulated serum precursor of protein AA, serum AA (SAA). The SAA-like amyloid fibril protein had a tendency to aggregate in neutral conditions, a phenomenon which is also seen in SAA but not in protein AA.
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