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  • Title: Contractile function, energy metabolism and myocardial structure at graded restriction of coronary blood flow.
    Author: Furkalo NK, Frolkis RA, Orlova NN, Gavrish AS.
    Journal: Cor Vasa; 1982; 24(5):372-80. PubMed ID: 7172690.
    Abstract:
    In closed-chest dogs, 30, 50 and 70% restriction of coronary blood flow was carried out by catheterization and autoperfusion of the circumflex branch of the left coronary artery. At 70% restriction, a mild decrease in most contractility indices was observed, without simultaneous impairment of the indices of systemic haemodynamics. Changes in energy metabolism appeared already in the initial stage of coronary insufficiency. A characteristic features at suppression of aerobic oxidation was an increase of the cAMP level of glycolytic activity of the pentoso-phosphate cycle, which ensured a sufficiently high ATP level in the myocardium. A limiting factor were disturbances in the system of energy transport (creatine phosphate, creatine phosphokinase) and of the calcium pump (Ca++-ATPase of the sarcoplasmic reticulum, SPR), which evidently led to a decrease of the inotropic properties of the myocardium at 70% restriction of coronary blood flow. Signs were found of structural lesions of the myofibrils and the SPR.
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