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  • Title: Effects of palmitoyl-CoA on the structure-function of the fatty acid synthetase complex from Ceratitis capitata.
    Author: Gavilanes JG, Lizarbe MA, Municio AM, Oñaderra M.
    Journal: Int J Biochem; 1982; 14(12):1061-6. PubMed ID: 7173488.
    Abstract:
    1. The effects of palmitoyl-CoA on the structure and enzyme activity of the fatty acid synthetase from the insect Ceratitis capitata have been examined. 2. The acyl-CoA derivative increases the helical content of the protein from 45 to 60% and inhibits the enzyme activity of the complex. 3. Bovine serum albumin, calf thymus histone H1 and phospholipids protect the enzyme from the inactivation by palmitoyl-CoA. Phospholipids increase also the ellipticity at 220 nm in the enzyme complex. 4. The results obtained show a non specific character for the inhibition and are interpreted in terms of the detergent properties of the long-chain acyl-CoA derivatives.
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