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  • Title: Heat-shock proteins in sea urchin embryos. Transcriptional and posttranscriptional regulation.
    Author: Roccheri MC, Sconzo G, Di Carlo M, Di Bernardo MG, Pirrone A, Gambino R, Giudice G.
    Journal: Differentiation; 1982; 22(3):175-8. PubMed ID: 7173525.
    Abstract:
    The production of heat-shock proteins in sea urchin embryos is accompanied by the appearance at the polysomal level of their relative mRNAs, as shown by their translation in a cell-free system; thus suggesting that the regulation of their production occurs at a transcriptional level. The mechanism for the inhibition of the bulk protein synthesis and for its reversal on the other hand should be looked for at a posttranscriptional level, since both these phenomena occur also in the presence of actinomycin D. The heat-shock proteins produced as early as at the mesenchyme blastula stage persist within the embryo at least till the pluteus stage.
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