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  • Title: Chemical and viral agents in prenatal experimental carcinogenesis.
    Author: Ivankovic S.
    Journal: Int J Biol Res Pregnancy; 1982; 3(3):99-102. PubMed ID: 7174146.
    Abstract:
    Malignant tumors are the second most common cause of death in children 0 to 15 years old. The typical organotropism of tumors in children is different than in adults aged 45-60 years. Due to the short induction periods, as well as the typical distribution of tumors, it is conceivable that various agents (chemicals, viruses) may induce carcinogenic effects during the prenatal life-span. It has been confirmed experimentally that certain chemicals, e.g., ethylnitrosourea, are potent prenatal carcinogens. Further, it is important to consider the especially high sensitivity of the fetus for chemical agents; this enhanced sensitivity is a major point of issue when discussing prenatal carcinogenesis. Results and conclusions obtained from prenatal carcinogenicity experiments should provide a basis for elucidating causes of cancer in children.
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