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  • Title: [Regional perfusion treatment in primary malignant melanomas of the extremities. (Microstage IV/V according to Clark and tumor thickness over 1.5 mm)].
    Author: Schraffordt Koops H, Oldhoff J.
    Journal: Hautarzt; 1982 Sep; 33(9):506-10. PubMed ID: 7174325.
    Abstract:
    During the period 1965-1976, 158 patients with stage I malignant melanoma of the extremities were treated by regional isolated perfusion with L-phenylalanine mustard (Melphalan) and local excision. In order to study local recurrence and survival, only patients with a primary melanoma Clark level IV or V and a tumor thickness of more than 1.5 mm were accepted in this study. The determinate survival in patients followed for 5-16 years is 74%; 20% developed positive regional lymph nodes. The local skin recurrence rate was 9% (14 patients); nine of these 14 patients simultaneously had distant metastases; the other five patients are alive with NED after retreatment. So far, this series of patients has shown no statistically significant difference in local recurrence after normothermic and hyperthermic perfusion: 2/19 (11%) and 12/132 (9%), respectively. However, mean tumor thickness in the patients treated by hyperthermic perfusion proved to exceed that in the normothermically perfused patients.
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