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  • Title: Fetal mortality associated with cleft lip and cleft palate.
    Author: Dronamraju KR, Bixler D, Majumder PP.
    Journal: Johns Hopkins Med J; 1982 Dec; 151(6):287-9. PubMed ID: 7176289.
    Abstract:
    Analysis of 1,516 pregnancies in sibships of probands with cleft lip with or without cleft palate [CL(P)], and 774 pregnancies in those of probands with isolated cleft palate (CP) indicated that fetal mortality significantly increases with liability to clefting. These data are compatible with the multifactorial two-threshold model, according to which a lower threshold level of liability results in a cleft formation whereas a higher level of liability causes a fetal death.
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