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  • Title: Androstenedione metabolism in human uterine tissues: endometrium, myometrium and leiomyoma.
    Author: Jasonni VM, Bonavia M, Lodi S, Preti S, Bulletti C, Flamigni C.
    Journal: J Steroid Biochem; 1982 Nov; 17(5):547-51. PubMed ID: 7176646.
    Abstract:
    Androstenedione was metabolized in vitro by human endometrium, myometrium and leiomyoma, to its 5 alpha-reduced metabolites: 5 alpha-androstan-3,17-dione (5 alpha-androstanedione) and androsterone as well as to testosterone, 17 beta-hydroxy-5 alpha-androstan-2-one (5 alpha-DHT) and 5 alpha-androstan-3 alpha,17 beta-diol (3 alpha-diol). Uterine tissue showed a similar enzymatic profile to the androgen responsive tissues; these data suggest that androgens may have a functional role in the uterine pathophysiology.
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