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  • Title: Scopolamine self-administration: cholinergic involvement in reward mechanisms.
    Author: Glick SD, Guido RA.
    Journal: Life Sci; 1982 Aug 30; 31(9):909-13. PubMed ID: 7176819.
    Abstract:
    Naive rats readily learned to self-administer scopolamine, a centrally active anticholinergic antimuscarinic agent, by the intravenous route; drug intake remained constant while response rates decreased with increasing unit dose ((0.005-0.02 mg/kg/infusion). Increases and decreases in scopolamine responding were elicited by pretreatment with muscarinic agonists and antagonists, respectively. An anticholinergic action at muscarinic synapses appears to be sufficient for reinforcing efficacy; such an action may mediate, in part, the addictive properties of other drugs (e.g., opiates and phencyclidine-like hallucinogens) that are known to have anticholinergic effects.
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