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  • Title: Adenovirus type 5 induces progression of quiescent rat cells into S phase without polyamine accumulation.
    Author: Cheetham BF, Shaw DC, Bellett AJ.
    Journal: Mol Cell Biol; 1982 Oct; 2(10):1295-8. PubMed ID: 7177112.
    Abstract:
    Adenovirus type 5 induces cellular DNA synthesis and thymidine kinase in quiescent rat cells but does not induce ornithine decarboxylase. We now show that unlike serum, adenovirus type 5 fails to induce S-adenosylmethionine decarboxylase or polyamine accumulation. The inhibition by methylglyoxal bis(guanylhydrazone) of the induction of thymidine kinase by adenovirus type 5 is probably unrelated to its effects on polyamine biosynthesis. Thus, induction of cellular thymidine kinase and DNA replication by adenovirus type 5 is uncoupled from polyamine accumulation.
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