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  • Title: The effect of combined treatment of hypoxic L5178Y-R and L5178Y-S cells with lidocaine and X-rays.
    Author: Niepokojczycka E, Budzicka E, Szumiel I.
    Journal: Neoplasma; 1982; 29(5):605-11. PubMed ID: 7177251.
    Abstract:
    Combination of lidocaine (6 mg/ml) and X-rays was used for treatment of two strains of L5178Y lymphoma cells under hypoxic conditions. The strains L5178Y-S (radiosensitive) and L5178Y-R (radioresistant) differ in radiosensitivity by a factor of about 1.4 whereas they are equally sensitive to lidocaine. For combined treatment of L5178Y-R cells the enhancement ratio was 1.4 and for that of L5178Y-S cells 1.0. Cell partition between two aqueous polymer phases [Dextran T500 and poly(ethylene glycol) 6000] does reflect neither viability nor the commitment of treated cells to interphase or reproductive death.
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