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  • Title: Tetrahydro-beta-carbolines: affinities for tryptamine and serotonergic binding sites.
    Author: Cascio CS, Kellar KJ.
    Journal: Neuropharmacology; 1982 Nov; 21(11):1219-21. PubMed ID: 7177348.
    Abstract:
    The affinities of four tetrahydro-beta-carbolines at [3H]tryptamine, [3H]5-HT (5-HT1), and [3H]spiperone (5-HT2) binding sites in rat cerebral cortex were investigated. The unsubstituted tetrahydro-beta-carboline was the most potent of the four compounds at all three binding sites, but was 200-400 times more potent at the tryptamine site than at either of the serotonin sites.
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