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  • Title: [Drug side effects as the probable cause of death. Results of the Berne Comprehensive Hospital Drug Monitoring Program].
    Author: Zoppi M, Török M, Stoller-Güleryüz D, Winzenried P, Marty H, Hess T, Stucki P, Bickel MH, Stocker F, Hoigné R.
    Journal: Schweiz Med Wochenschr; 1982 Dec 04; 112(49):1808-10. PubMed ID: 7178881.
    Abstract:
    During the years 1974-1980, 19 of 17,285 inpatients of the divisions of internal medicine of two teaching hospitals showed a probable or definite adverse drug reaction (ADR) which was considered to be a major cause of death. In 7 patients the decisive ADR occurred during the hospital stay. The overall mortality from ADR is 0.040%. For each therapeutic group of drugs the following rate of drug-related death was calculated: for anticoagulants 0.047% (3/6378 inpatients), for cardiac glycosides 0.016% (1/6368), for analgesic/antirheumatic drugs 0.014% (1/7112) and for cytostatic drugs 0.38% (2/531). In 12 patients the ADR was already present on hospital admission.
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