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  • Title: Effects of genetically different strains of mice on the microsomal activation of 2-aminofluorene.
    Author: Bender J, Razdan R, Lumb JR, Sheehy RJ.
    Journal: Toxicol Lett; 1982 Sep; 13(1-2):139-42. PubMed ID: 7179303.
    Abstract:
    Five strains of mice were examined for microsomal cytochrome P450 (Cyt P450) activity and ability of the microsomal preparation to activate 2-aminofluorene (2-AF) to its mutagenic form. Each strain was assayed under normal and induced conditions. Group A strains known to be easily induced to carcinogenesis by chemicals (C57BL/6J and BALB/cJ) showed higher levels of Cyt P450 and increased mutagenesis activity of the metabolized 2-AF than Group B strains which are known to be high spontaneous tumor producers (CE/J, A/HeJ, C3H/HeJ). Induction of the hepatic microsomes with Aroclor 1254 increased the difference between the two groups.
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