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  • Title: Immunotherapy with grass pollen major allergens. Immunological results from a prospective 3-year double blind study.
    Author: Osterballe O, Løwenstein H, Norn S, Prahl P, Skov P, Skov PS, Weeke B.
    Journal: Allergy; 1982 Oct; 37(7):491-501. PubMed ID: 7181048.
    Abstract:
    Preseasonal hyposensitization stimulated an intercorrelated increase in both serum-specific IgE and allergen-specific IgG. Subsequent perennial treatment depressed the stimulated IgE response and the basophil cell sensitivity, whereas the allergen-specific IgG response showed further increase and persisted at a high level. Nasal IgE response was stimulated from the second pollen season and subsequently became depressed. One year after the end of hyposensitization the allergen-specific IgG response had fallen by 25-50%.
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