These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Plasma kinetics of digoxin in the cat.
    Author: Bolton GR, Powell W.
    Journal: Am J Vet Res; 1982 Nov; 43(11):1994-9. PubMed ID: 7181198.
    Abstract:
    The biological half-life of digoxin was 33.3 +/- 9.5 hours in 6 cats after a single IV injection. Longer half-lives were obtained after chronic oral administration, indicating that digoxin elimination is capacity-limited in the cat. The mean percentage of urinary excretion of digoxin after a single IV dose was 45% +/- 9.7% over a 10-day period. Toxic plasma concentrations ranged from 2.4 to 2.9 ng/ml, and 5 of 6 cats had clinical signs of toxicosis at concentrations greater than 2.6 ng/ml. Prolongation of the PQ interval was seen on the ECG at nontoxic plasma concentrations in 4 of 6 cats. The most striking ECG evidence of digoxin toxicosis was ST-segment elevation seen in 3 of the 6 cats.
    [Abstract] [Full Text] [Related] [New Search]