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  • Title: Spinocerebellar degeneration secondary to chronic intestinal malabsorption: a vitamin E deficiency syndrome.
    Author: Harding AE, Muller DP, Thomas PK, Willison HJ.
    Journal: Ann Neurol; 1982 Nov; 12(5):419-24. PubMed ID: 7181449.
    Abstract:
    Two adults are described who developed a progressive neurological disorder more than 20 years after the onset of chronic fat malabsorption. The clinical features included dysarthria, cerebellar ataxia, and prominent proprioceptive loss with depressed or absent tendon reflexes. Serum vitamin E was undetectable in both cases. One patient improved clinically and electrophysiologically after oral therapy with vitamin E. The findings in these patients were similar to those in others recently reported with vitamin E deficiency associated with biliary atresia. Electrophysiological observations suggested that the human deficiency state parallels that found neuropathologically in vitamin E-deficient animals.
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