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  • Title: Interaction of povidone-iodine compounds, phagocytic cells, and microorganisms.
    Author: Van den Broek PJ, Buys LF, Van Furth R.
    Journal: Antimicrob Agents Chemother; 1982 Oct; 22(4):593-7. PubMed ID: 7181472.
    Abstract:
    The interaction between povidone-iodine, phagocytic cells, and microorganisms was studied. Three preparations of povidone-iodine were investigated: commercially available povidone-iodine solution Betadine, pure high-molecular-weight povidone-iodine as used in Betadine, and a low-molecular-weight povidone-iodine. Low concentrations of povidone-iodine (approximately 0.005%) have considerable activity in vitro. The concentrations used clinically (0.1 to 20%) are toxic for granulocytes and monocytes. Leukocytes reduce the in vitro microbicidal activity of povidone-iodine. No differences of any importance were found between the three preparations of povidone-iodine.
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