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  • Title: The effect of X-537A (lasalocid) on potassium contracture in rat ventricular muscle.
    Author: Lehr JT, Gaide MS, Ezrin AM, Wiggins J, Bassett AL.
    Journal: Arch Int Pharmacodyn Ther; 1982 Sep; 259(1):106-11. PubMed ID: 7181574.
    Abstract:
    The effects of the carboxylic ionophore X-537A on contracture induced by high external K+ were determined in stimulated and unstimulated rat papillary muscles. X-537A (5 X 10(-6) M - 10(-5) M) increased peak K+-contracture force in stimulated but not unstimulated muscle. X-537A may alter myocardial force development by influencing transport of Ca2+ across the sarcolemma or Ca2+ release from sarcoplasmic reticulum.
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