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  • Title: Synthesis of derivatives of beta-aminomethyl-gamma-(p-chlorophenyl)-gamma-hydroxybutyric acid.
    Author: Jakóbiec T, Zabska R, Zawisza T.
    Journal: Pol J Pharmacol Pharm; 1982; 34(4):239-46. PubMed ID: 7182845.
    Abstract:
    Several new derivatives of beta-aminomethyl-gamma-(p-chlorophenyl)-gamma-hydroxybutyric acids have been obtained. The substrates, beta-aminomethyl derivatives of gamma-(p-chlorophenyl)-tetrahydrofuranone-2 1-4, were converted by the reactions of ammonolysis, aminolysis and hydrazinolysis into appropriate amides and hydrazides of beta-aminomethyl-gamma-(p-chlorophenyl)-gamma-hydroxybutyric acid. Compounds 10, 11, 16, 18, 19 and 20 show depressant activity on CNS, while compounds 6 and 8 demonstrate antiinflammatory action.
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