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  • Title: The penetration of flucloxacillin into cortical and cancellous bone during arthroplasty of the knee.
    Author: Holm S, Larsson SE.
    Journal: Int Orthop; 1982; 6(4):243-7. PubMed ID: 7183576.
    Abstract:
    Antibiotic prophylaxis with 2 g flucloxacillin was given 2 h before operation in 23 adult patients undergoing knee replacement operations for rheumatoid arthritis or osteoarthrosis. The mean extracted concentration of flucloxacillin obtained at operation was 12.9 micrograms/ml (SD 5.25) in synovial fluid; 2.9 micrograms/g (SD 3.59) in synovium; 2.0 micrograms/g (SD 1.48) in cancellous bone and 1.3 micrograms/g (SD 1.25) in cortical bone. The minimum inhibiting concentration (MIC) value for flucloxacillin was usually 0.25 micrograms/g against Staphylococcus aureus. Therapeutically active concentrations were thus obtained. There were no adverse reactions from the antibiotic administration.
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