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  • Title: Effects of variations in time and dose of diazepam injection on delayed hypersensitivity.
    Author: Descotes J, Laschi A, Tachon P, Tedone R, Evreux JC.
    Journal: J Immunopharmacol; ; 4(4):279-84. PubMed ID: 7184962.
    Abstract:
    Administration of diazepam was suggested to exert immuno-suppressive properties in mice. In the present study, we explored the time and dose-dependence of diazepam effects on delayed hypersensitivity to sheep erythrocytes in Balb/c mice. DTH response was only depressed when diazepam was injected shortly after immunization and this effect on DTH induction was found with doses of 4 and 8 mg/kg ip while lower doses (0, 5, 1 and 2 mg/kg) remained ineffective.
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