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  • Title: The role of methemoglobin in acute butyl nitrite toxicity in mice.
    Author: McFadden DP, Carlson GP, Maickel RP.
    Journal: Fundam Appl Toxicol; 1981; 1(6):448-51. PubMed ID: 7185595.
    Abstract:
    When mice were exposed to butyl nitrites in an inhalation chamber, a significant level of methemoglobinemia is produced. The potency order for methemoglobin production of the four butyl nitrites (n-, iso-, sec-, tert-) is the same as that of their lethal concentrations (LC50 values) and parallels the ability of the agents to cause methemoglobin formation in mouse erythrocytes in vitro. Pretreatment with a single dose of methylene blue prevents the methemoglobin formation and protects against the lethality of the butyl nitrites.
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