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  • Title: Cholinergic agonist-induced down regulation of neuronal alpha-bungarotoxin receptors.
    Author: Messing A.
    Journal: Brain Res; 1982 Jan 28; 232(2):479-84. PubMed ID: 7188033.
    Abstract:
    The ability of cholinergic ligands to regulate neuronal alpha-bungarotoxin receptor number was studied in dissociated monolayer cultures of embryonic chick ciliary ganglion neurons. Carbamylcholine and nicotine, but not D-tubocurarine, caused a loss of 25% of the surface [125I]alpha-bungarotoxin receptors within 1 h at 37 degrees C. This receptor loss occurred without change in affinity for [125I]alpha-bungarotoxin, was temperature-sensitive and was prevented by co-incubation with D-tubocurarine.
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