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  • Title: [Murine near-diploid cell clones: a model for the genetic analysis of signs of transformation].
    Author: Stromskaia TP, Kopnin BP, Stavrovskaia AA.
    Journal: Vopr Onkol; 1980; 26(3):50-5. PubMed ID: 7189309.
    Abstract:
    Several near-diploid clones were obtained from the established mouse cell line, CAK-7. These clones proved to be highly oncogenic in syngeneic irradiated mice (TD50 = 1 x 10(2)--2 x 10(3). They differed in plating efficiency in semi-solid medium (from 5 x 10(-3) to 22 x 10(-5)). There was no correlation between tumorigenicity of the cells and their plating efficiency in methylcellulose. The differences between clones able to form anchorage-independent clonies would permit their use for the genetic analysis of this kind of malignancy.
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