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  • Title: [Contribution to the analysis of the hypoglycaemic agent tolbutamide. Part 2 (author's transl)].
    Author: Oelschläger H, Blume H.
    Journal: Arzneimittelforschung; 1980; 30(4):581-4. PubMed ID: 7190395.
    Abstract:
    The chemical identification reaction for tolbutamide (USP 1975) involves its hydrolysis by sulphuric acid with the formation of n-butylamine. This amine then reacts with diazotised p-nitraniline to give 8 red or yellow coloured compounds. A radicalic and an ionic mechanism for their formation, which are partially interrelated, are discussed. Other oral sulphonamide-hypoglycaemic agents give a positive result with this identification reaction.
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