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  • Title: Amantadine reduces haloperidol-induced dopamine receptor hypersensitivity in the striatum.
    Author: Allen RM, Lane JD, Brauchi JT.
    Journal: Eur J Pharmacol; 1980 Jul 25; 65(2-3):313-5. PubMed ID: 7190503.
    Abstract:
    In this report evidence is presented that amantadine hydrochloride greatly reduced the development of dopaminergic receptor hypersensitivity in the striatum, which normally results following chronic haloperidol administration using both a stereotyped behavior bioassay and a [3H]spiroperidol receptor binding assay. Amantadine prophylaxis reduced maximal ligand binding to near control levels and also significantly reduced apomorphine induced stereotypy. These results clearly demonstrate that amantadine greatly reduced haloperidol-induced striatal dopamine receptor hypersensitivity and support the hypothesis that amantadine given concurrently with neuroleptic agents might serve to prevent the development of human tardive dyskinesia.
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