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  • Title: Specificity in the hydrolysis of N-acyl-L-phenylalanine 4-nitroanilides by chymotrypsin.
    Author: Jakubke HD, Däumer H, Könnecke A, Kuhl P, Fischer J.
    Journal: Experientia; 1980 Sep 15; 36(9):1039-40. PubMed ID: 7191374.
    Abstract:
    The affinity of N-acyl-L-phenylalanine 4-nitroanilides for chymotrypsin is enhanced as the hydrophobicity of non-amino acid residues in the P2-position of the substrates increases, whereas Kcat remains nearly constant. On the other hand, if alanine or leucine is in the P2-position Kcat increases with decreasing KM.
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