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  • Title: Biochemical aspects of chemical carcinogenesis.
    Author: Gielen JE.
    Journal: Bull Cancer; 1978; 65(3):249-54. PubMed ID: 719180.
    Abstract:
    This article briefly outlines three major biochemical problems in relation to the presence of chemical carcinogens in mammalian cells: (a) the enzymatic systems responsible for the chemical carcinogen metabolism; (b) the nature of the reactive metabolites and (c) the cellular target(s). References and examples are only given for the field of the polycyclic aromatic hydrocarbons.
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