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  • Title: [The influence of food on the bioavailability of drugs on the example of sulfamethoxydiazine (author's transl)].
    Author: Kaumeier HS.
    Journal: Arzneimittelforschung; 1980; 30(10):1794-800. PubMed ID: 7192117.
    Abstract:
    It is demonstrated that the bioavailability of sulfamethoxydiazine (Durenat), taken as an example, is much better when administered simultaneously with a test meal than when given in the fasting state. Also a high-lipid meal in comparison with a high-protein or high-carbohydrate meal considerably improves the bioavailability of sulfamethoxydiazone. Food as well as the composition of food are likely to have short-term and long-term consequences on absorption and biotransformation and therefore influence the bioavailability of drugs.
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