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  • Title: The origin of 1-(3-pyridyl-N-oxide)ethanol as a metabolite of 3-acetylpyridine.
    Author: Damani LA, Bryan J, Cowan DA, Gorrod JW.
    Journal: Xenobiotica; 1980; 10(7-8):645-53. PubMed ID: 7192450.
    Abstract:
    1. 3-Acetylpyridine was metabolized extensively to 1-(3-pyridyl)ethanol when the hepatic enzyme source was the soluble fraction (140,000 g supernatant). 3-Acetylpyridine-N-oxide was identified as a metabolite using the 10,000 g or the microsomal fraction. 2. 1-(3-Pyridyl-N-oxide)ethanol was not detected as a metabolite of 1-(3-pyridyl)ethanol using tissue preparations. However, 3-acetylpyridine was formed in trace amounts when the alcohol was incubated with the 10,000 g or the microsomal fraction. 3. Incubation of 3-acetylpyridine-N-oxide with the soluble or 10,000 g fraction resulted in the formation of 1-(3-pyridyl-N-oxide)ethanol (keto-reduction) as the major metabolite. 3-Acetylpyridine was formed in trace amounts (N-oxide reduction) with the 10,000 g and the microsomal fractions.
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