These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Adrenergic control of bicarbonate absorption in the proximal convoluted tubule of the rat kidney.
    Author: Chan YL.
    Journal: Pflugers Arch; 1980 Nov; 388(2):159-64. PubMed ID: 7192853.
    Abstract:
    The effects of norepinephrine and phenoxybenzamine on bicarbonate absorption in the rat proximal convoluted tubules were studied by simultaneous microperfusion of tubule and peritubular capillaries. Bicarbonate was determined by using a pH-sensitive membrane electrode system. The rates of bicarbonate absorption (JHCO3) were examined in the same proximal tubule before and after the addition of norepinephrine or phenoxybenzamine. When the proximal tubule was perfused with Ringer solution and peritubular capillaries were perfused with albumin Ringer solution, JHCO3 was 145 +/- 3.3 pEq/min X mm. Addition of 2 X 10(-6) mol/l norepinephrine to the capillary perfusate caused a 21% increase in JHCO3. Addition of 2 X 10(-6) mol/l phenoxybenzamine to the capillary perfusate caused a 12% decrease in JHCO3. Addition of both norepinephrine and phenoxybenzamine to the capillary perfusate caused a 19% decrease in JHCO3. However, there was no significant effect on JHCO3 observed when either norepinephrine or phenoxybenzamine was added to the luminal perfusate. These results suggest that adrenergic nerves participate in the regulation of renal tubular bicarbonate absorption through the direct action of norepinephrine on adrenergic receptors located at the basolateral side of the proximal tubule.
    [Abstract] [Full Text] [Related] [New Search]