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  • Title: Effects of nimodipine (Bay e 9736) on cerebral circulation in cats.
    Author: Tanaka K, Gotoh F, Muramatsu F, Fukuuchi Y, Amano T, Okayasu H, Suzuki N.
    Journal: Arzneimittelforschung; 1980; 30(9):1494-7. PubMed ID: 7193015.
    Abstract:
    The response of feline pial arteries to i.v. administration of isopropyl-(2-methoxyethyl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate (nimodipine, Bay e 9736) was studied by means of the vidicon camera system developed in our laboratory. Pial arteries showed a dose-dependent dilation with a reduction of systemic arterial blood pressure in the dose range of 0.001 mg/kg to 0.1 mg/kg of nimodipine. The dilatory response was more marked in the smaller arteries (< 100 mu) than in the larger ones (greater than or equal to 100 mu).
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