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  • Title: Induction of sister-chromatid exchanges and chromosome aberrations by gamma-irradiated nucleic acid constituents in CHO cells.
    Author: Wilmer JW, Natarajan AT.
    Journal: Mutat Res; 1981 Jan; 88(1):99-107. PubMed ID: 7193801.
    Abstract:
    Chinese hamster ovary (CHO) cells were exposed to different concentrations of hydrogen peroxide and to gamma-irradiated, oxygenated solutions of thymine, thymidine and 2-deoxy-D-ribose. By using a modified BrdUrd-labelling method sister-chromatid exchanges (SCEs) and chromosomal aberrations were scored in the same cell populations, one cycle after treatment. Irradiated, oxygenated solutions of 2-deoxy-D-ribose clearly induced SCEs and chromosomal aberrations. In comparison, hydrogen peroxide and irradiated solutions of thymine and thymidine were less effective in CHO cells.
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