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  • Title: Hypolipaemic activity of 1-(theophyllin-7-yl)-ethyl-2-[2-(p-chlorophenoxy)-2-methylpropionate] (etofylline clofibrate) and its analogues in normolipaemic rats.
    Author: Ginocchio AV, Metz G.
    Journal: Arzneimittelforschung; 1980; 30(11b):2032-4. PubMed ID: 7194054.
    Abstract:
    The hypolipaemic potential of 1-(theophyllin-7-yl)-ethyl-2-[2-(p-chlorophenoxy)-2-methylpropionate] (etofylline clofibrate, ML 1024, Duolip) was assessed in conjunction with a series of analogous new theophylline derivatives and clofibrate (CPIB) by a short-term screening test in normolipaemic rats. The significant cholesterol and triglyceride-lowering effect of ML 1024 was comparable to that observed for CPIB over the 50-300 mg/kg dose range evaluated and contrasted with the relative inactivity associated with its chemical analogues.
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