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  • Title: [Myocardial protection by a carnosine-buffered cardioplegic solution (author's transl)].
    Author: Gercken G, Bischoff H, Trotz M.
    Journal: Arzneimittelforschung; 1980; 30(12):2140-3. PubMed ID: 7194076.
    Abstract:
    A carnosine-buffered, Na+-poor and Ca2+-free cardioplegic solution with pH 7.40 and physiological osmolarity was developed. The effect on the myocardium was more protective than that obtained with a corresponding unbuffered solution or a Mg-aspartate-procaine solution. The metabolic state of rabbit hearts was investigated up to 8 h of ischemia at 15 degrees C. A constant glycolytic rate was observed up to 6 h and the ATP content was maintained at 83% of controls. The ratio of glycolytic ATP production vs. total turnover of high-energy phosphates was 0.85. The small difference between energy demand and production may effect the conditions for good recovery.
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